Do Weight-Loss Treatments Work Differently for Men and Women? The Facts
Obesity affects men and women differently — and so should treatment.
Men usually have more visceral fat (deep abdominal fat) and often lose weight slightly faster with structured diet and exercise. Women may see smaller early drops on the scale but gain greater heart and metabolic benefits for every kilogram lost. Hormonal life stages — such as pregnancy, perimenopause, and menopause — also influence appetite, metabolism, and where fat is stored.
That’s why weight-loss programs that account for menstrual cycle phases or menopause symptoms often feel more effective and sustainable for many women.
Medications and Sex Differences
Modern anti-obesity medications, such as GLP-1 receptor agonists, show meaningful differences between men and women.
- Effectiveness: Women tend to achieve equal or slightly greater percentage weight loss than men at similar doses.
- Side effects: Women more often report gastrointestinal symptoms like nausea, reflux, or a feeling of fullness.
- Management: Gradual dose increases, balanced nutrition, and monitoring iron and B-vitamin levels can help women stay comfortable and consistent with treatment.
- Men’s response: Men often see quicker improvements in blood pressure, fatty liver, and sleep apnoea due to faster reductions in visceral fat.
These differences highlight the importance of personalised treatment plans that address hormonal and biological variations rather than using a one-size-fits-all approach.
Surgery and Gender Considerations
Bariatric surgery is highly effective for both men and women, but some sex-specific factors should be considered. Procedures such as sleeve gastrectomy and gastric bypass lead to significant, lasting weight loss and remission of related conditions like type 2 diabetes.
For women:
- They often require proactive micronutrient supplementation (especially iron, folate, and vitamin B12).
- Pregnancy should be avoided for 12–24 months after surgery while weight stabilises.
For men:
- They typically experience rapid improvement in sleep apnoea and metabolic health soon after surgery.
Ultimately, the choice of procedure depends on personal factors — including reflux, diabetes control, BMI, age, and fertility plans — not gender alone.
Personalised Care at 360 SURGERY Melbourne
At 360 SURGERY in Melbourne, we design every obesity treatment plan around the individual — considering biology, hormones, health goals, and life stage.
Whether you are exploring:
• Evidence-based weight-loss medication
• Bariatric surgery, or
• A combination of both,
our surgeon-led, multidisciplinary team tailors care to your needs and supports long-term success.
Key Takeaway
Men and women respond differently to weight-loss treatments due to variations in fat distribution, hormonal balance, and metabolism. The most effective programs are those that recognise and adapt to these biological differences while focusing on overall wellbeing and sustainability.
If you are ready to explore your options, book a consultation with our experienced team at 360 SURGERY Melbourne.
Reference:
Kantowski T, Schulze Zur Wiesch C, Aberle J, Lautenbach A. Obesity management: sex-specific considerations. Arch Gynecol Obstet. 2024 May;309(5):1745–1752. doi: 10.1007/s00404-023-07367-0.



