Effective Tips for Managing Common GLP-1 Side Effects Wegovy® (Semaglutide) and Mounjaro® (Tirzepatide) | 360 SURGERY Melbourne
GLP-1 receptor agonists such as Wegovy® (semaglutide) and Mounjaro® (tirzepatide) are powerful tools for long-term weight management. They work by regulating appetite, improving insulin sensitivity, and slowing stomach emptying. However, like any medication, they may cause side effects, particularly during the first few weeks of treatment.
At 360 SURGERY Melbourne, we help patients achieve their health goals safely and effectively. Here are some practical tips to manage the most common side effects of GLP-1 medications, so you can stay on track with your weight loss journey.
1. Nausea
Nausea is one of the most reported side effects of GLP-1 medications, especially when doses are increased. These strategies may help:
- Eat smaller, more frequent meals: Large meals can trigger nausea.
- Avoid fatty or spicy foods: These can irritate your stomach further.
- Stay well-hydrated: Sip water or herbal teas slowly throughout the day.
- Choose bland foods: Toast, rice, and crackers are easier to tolerate.
- Take your injection at bedtime: This can reduce awareness of nausea during the day.
2. Diarrhoea
This is typically mild and short-term but can be managed with the following tips:
- Stay hydrated: Replenish fluids and electrolytes to prevent dehydration.
- Follow a low-fibre diet temporarily: Stick to easy-to-digest foods like bananas, applesauce, rice, and toast (the BRAT diet).
- Avoid caffeine and alcohol: These irritants can worsen diarrhoea.
- Try probiotics: They may support gut health and digestive balance.
3. Constipation
Constipation may occur as your digestive system adjusts. The following can help:
- Increase fibre intake: Add fruits, vegetables, and whole grains to your meals.
- Stay physically active: Regular movement promotes bowel motility.
- Drink plenty of water: Fluid intake is key for regular bowel movements.
- Use a fibre supplement: Products like psyllium husk may provide relief.
4. Stomach Pain or Cramps
Abdominal discomfort can occur, particularly after meals. Try the following:
- Eat slowly and chew thoroughly: This supports smoother digestion.
- Avoid lying down immediately after eating: Wait 1–2 hours before reclining.
- Use a warm compress: Applying heat to the abdomen may reduce cramping.
- Consult your doctor if pain persists: Persistent or severe pain may indicate a more serious issue such as pancreatitis. Seek medical review promptly.
5. Headaches
Headaches may occur during the adjustment phase and are often linked to hydration or blood sugar changes.
- Stay hydrated: Dehydration is a common trigger for headaches.
- Rest in a dark, quiet room: Reduces stimulation and allows recovery.
- Use over-the-counter pain relief: Paracetamol is generally safe, but check with your doctor.
6. Fatigue or Low Energy
Feeling tired or lethargic can be frustrating. These tips may help restore energy:
- Prioritise good sleep hygiene: Stick to a regular sleep schedule and minimise screen time before bed.
- Balance activity and rest: Light movement (like walking) can improve energy levels.
- Monitor blood sugar levels: Hypoglycaemia may occur in some cases—especially if you’re on other medications. Discuss with your doctor if necessary.
7. Injection Site Reactions
Mild swelling, redness, or discomfort at the injection site is common.
- Rotate injection sites: Avoid using the same area repeatedly.
- Apply an ice pack: Before and after the injection to reduce swelling.
- Keep the area clean: Prevents infection or irritation.
How to Stay on Track with Your GLP-1 Treatment
Mild side effects are common and often improve over time. The key is to remain consistent with your medication and use supportive strategies to manage symptoms.
At 360 SURGERY, we specialise in bariatric surgery and medical weight loss in Melbourne. Our team offers tailored support to help you navigate side effects, adjust your plan, and achieve long-term results safely.
When to Seek Medical Advice
Always contact your healthcare provider if:
- Side effects persist or worsen
- You experience severe abdominal pain
- You have signs of dehydration (dizziness, dry mouth, dark urine)
- You notice signs of an allergic reaction (rash, swelling, shortness of breath)
Contact 360 SURGERY Melbourne
If you’re using Wegovy or Mounjaro and experiencing side effects, speak to our team today. We’ll provide personalised guidance to help you manage your medication safely and effectively.


